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Free Radical Research Volume 46, 2012 - Issue 2
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Research Articles

Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production

Li XiaoDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Yan GeDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Lin SunDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Xiaoxuan XuDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Ping XieDepartment of Pathology and Medicine, Northwestern University, Chicago IL USA
,
Ming ZhanDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Ming WangDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Zheng DongDepartment of Cellular Biology and Anatomy, Medical college of Georgia, 1459 Laney Walker Blvd, Augusta, GA
,
Jun LiDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Shaobin DuanDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
,
Fuyou LiuDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR China
&
Ping XiaoDepartment of Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan PR ChinaCorrespondence[email protected]
 show all
Pages 174-183 | Received 12 Sep 2011, Accepted 05 Dec 2011, Published online: 23 Jan 2012
 
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Abstract

Albumin induced epithelial-mesenchymal transition (EMT) of renal tubular cells through reactive oxygen species (ROS) pathway plays an important role in tubulointerstitial fibrosis. Cordycepin (3 -deoxyadenosine), a potential antioxidant, was demonstrated to have various pharmacological effects and could inhibit EMT of some cells. However, the role of cordycepin on albumin-induced EMT in renal tubular cells (HK2) is unclear. In this study, we investigated the effect of cordycepin on albumin-induced EMT of HK2 cells and its mechanisms. HK-2 cells were exposed to bovine serum albumin with or without pretreatment with cordycepin. Results showed that albumin significantly induced EMT formation of HK-2 which associated with NADPH oxidase activation and intracellular ROS overproduction through increased Rac1 activity and expression of NOX4, p22phox and p47phox, while these effects were abolished in that pretreated with cordycepin. In conclusion, cordycepin could ameliorate albumin-induced EMT of HK2 cells by decreasing NADPH oxidase activity and inhibiting ROS production.

This paper was first published online on Early Online on 23 January 2012.

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