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Abstract
Previously, the adhesion of polymer to internal tissue has been found to depend on the attachment of small hydrophobic molecules to the substrate to promote compatibility at the interface. An adhesive system has been formulated based on this finding comprising benzoyl chloride and a solution of silicone in methylene chloride. In this study, methods for the purification, sterilization and stability testing of the three components of this adhesive are described. The methylene chloride and the silicone component have little effect on the healing rate of incisions inflicted on the dorsal skin of Wistar rats. However, the maximum amount of benzoyl chloride which may be applied without delaying the healing is limited to 2 μl/cm2. When the optimal amount is not exceeded, these three components can be used together as an adhesive system and incisions as long as 10 cm in length on the back of Wistar rats have been closed with this admixture. The elimination and distribution of 14C-labelled benzoyl chloride in Wistar rats are very similar in many respects to that of the non-toxic benzoic acid. Histological studies are in progress for further characterization of this silicone adhesive system.