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Abstract
Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded poly-electrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity. This might be due to the presence of both sulfamate and carboxylate groups arranged in a steric manner in the molecule as that of Heparin. Surface energy parameters, platelet adhesion and plasma recalcification time were investigated. Possible comparison with heparin had been demonstrated.