Protein and Platelet Interactions with Polymer Surfaces

D. R. Absolom Research Institute, the Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 1A4; Department of Microbiology, State University of New York at Buffalo, Buffalo, New York, 14214., USA

W. Zingg Research Institute, the Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 1A4; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, M5S 1A4

C. J. Van Oss Department of Microbiology, State University of New York at Buffalo, Buffalo, New York, 14214., USA; Department of Chemical Engineering, State University of New York at Buffalo, Buffalo, New York, 14214, USA

A. W. Neumann Research Institute, the Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8; Department of Mechanical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 1A4; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 1A4

Abstract

An attempt is made to develop an understanding of the basic mechanism governing the interaction of the major blood proteins and cells with polymer surfaces with a focus on thermodynamic approach. It is believed that such investigations may be helpful to provide a rational for the design of suitable cardiovascular prosthetic materials and to choose materials in such a way that adsorption of certain proteins eg. ‘fibrinogen’ is thermodynamically unfavourable compared to adsorption of other proteins eg. ‘albumin’.

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Protein and Platelet Interactions with Polymer Surfaces

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Protein and Platelet Interactions with Polymer Surfaces

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