Abstract
When tested In mice bearing the Lewis lung tumor with 2, 3, or 4 Gy dally for 5 days, SBHS produced a dose-modifying factor of 1.6 that was increased to 2.1 with carbogen. The addition of SBHS (1.32 gm protein/kg) to treatment with melphalan (MEL) resulted in a 2.2-fold increase in the tumor growth delay (TGD). The combination of SBHS with carbogen (6 h) produced a 3.6-fold increase in TGD compared with MEL alone. The addition of SBHS to treatment with cyclophosphamide (CTX) resulted in a 2-fold increase In the TGD. However, the combination of SBHS and carbogen was much more effective resulting In a 4.6-fold increase In TGD. There was a 1.3-fold Increase in TGD with SBHS and CDDP compared with CDDP alone. The combination of SBHS and carbogen was a more effective addition to CDDP resulting in a 1.9-fold increase in TGD. The addition of SBHS to treatment with BCNU increased the TGD produced by BCNU by 1.5-fold. The comblnaμon of SBHS/BCNU and carbogen resulted In a 2.3-fold increase In TGD over that obtained with BCNU alone.