Association between plasminogen activator inhibitor-1 4G/5G gene polymorphism and immunoglobulin A nephropathy susceptibility

Abstract

The association between plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene polymorphism and immunoglobulin A nephropathy (IgAN) risk is still controversial. A meta-analysis was performed to evaluate the association between PAI-1 4G/5G gene polymorphism and IgAN susceptibility. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic database. Four articles were identified for the analysis of association between PAI-1 4G/5G gene polymorphism and IgAN risk. 4G allele was not associated with IgAN susceptibility in overall populations and in Asians. Furthermore, 4G/4G and 5G/5G genotype were not associated with IgAN for overall populations, Asians. In conclusion, PAI-1 4G/5G gene polymorphism was not associated with IgAN risk in overall populations and in Asians. However, more studies should be performed in the future.

• 4G/5G
• gene polymorphism
• immunoglobulin A nephropathy
• meta-analysis
• plasminogen activator inhibitor-1

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the sub-item of 985 Project Foundation of Sun Yat-Sen (The Hundred Talents Program Foundation; No. 88000-3311300).