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Journal of Receptors and Signal Transduction Volume 35, 2015 - Issue 6
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Review Article

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

Yu SunDepartment of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. China
,
Wen-Zhou LiuDepartment of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. China
,
Tao LiuDepartment of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. China
,
Xu FengDepartment of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. China
,
Nuo YangDepartment of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. China
&
Hua-Fu ZhouDepartment of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, Nanning, P.R. ChinaCorrespondence[email protected]
Pages 600-604 | Received 06 Feb 2015, Accepted 12 Mar 2015, Published online: 22 Jun 2015
 
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Abstract

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.

Declaration of interest

The authors report no conflicts of interest.

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