The microRNA regulatory network: a far-reaching approach to the regulate the Wnt signaling pathway in number of diseases

Abstract

Wnt signaling pathway plays an important role in cell renewal, tumorigenesis, organogenesis, bone formation and bone resorption. Wnt signaling pathway is divided into two outlets: Wnt-β-catenin pathway (canonical pathway) and Wnt-calcium pathway (non-canonical pathway). miRNAs play a key role in the regulation of Wnt signaling pathway. In this review, we highlight the basic indulgent of miRNAs-mediated regulation of Wnt signaling pathway. We focus on the role of miRNAs at different levels of Wnt signaling: signaling molecules, their associated signaling proteins, regulatory proteins, transcription factors and related cytokines. Finally, we concluded that these multiple levels of targeting may have diagnostic potential as well as therapeutic prospective in future treatment.

• MicroRNA
• signal transduction
• therapeutics
• Wnt signaling pathway

Acknowledgement

We are really thankful to Muneeb Haider for his contribution in the pictorial representation of pathway.

Declaration of interest

The authors declare no conflicts of interest. The efforts of all the authors are highly appreciable. They all have contributed equally. We would also like to acknowledge the great support of Asima Zia for reviewing. We are really grateful to recognize the efforts of all the lab members at Immunogenetics Lab., ASAB, NUST, Islamabad.