The GPCR Great Lakes Retreat is an annual joint meeting with Club des Recepteurs – a Sept Domains Transmembranaires du Quebec. This meeting has evolved to be a prestigious and extremely active venue for interaction of students, post-doctoral fellows, and principal investigators from academia and industry, all convening to discuss the marvelous allosteric machine – that is the Seven Transmembrane Receptor. Continuing a tradition begun with the reporting of the proceedings of the 2007 Great lakes Meeting in Journal of Receptors and Signal Transduction (J.R.S.T. Vol 28:3–14, 2008), the journal is pleased to present papers from the 2014 meeting held and the Chateau Bromont in Bromont (Quebec), Canada, in this issue. It is hoped that some of the excitement of this meeting is conveyed in these papers as the interface of seven transmembrane receptors with complex signaling mechanisms. Currently it is undergoing a Renaissance of interest due to the availability of new assay technologies to see receptor behavior.
