Improvement of water solubility and in vitro dissolution rate of aceclofenac by complexation with β-cyclodextrin and hydroxypropyl-β-cyclodextrin

Abstract

The present study deals with the inclusion complexation of aceclofenac with β-cyclodextrin by grinding, microwave and spray-drying techniques. A derivative of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, was also subjected to the complexation process with aceclofenac by spray-drying technique. The samples were subjected to in-vitro dissolution studies, fourier transform infra-red spectroscopy, differential scanning calorimetry, nuclear magnetic resonance spectroscopy and x-ray diffraction studies. The in-vitro dissolution of aceclofenac-hydroxypropyl-β-cyclodextrin complex was faster as compared to the aceclofenac- β-cyclodextrin complex and aceclofenac alone. Spray-dried aceclofenac-β-cyclodextrin complex were subjected to anti-inflammatory and analgesic activity and showed significant anti-inflammatory and analgesic activity.

Keywords::

• Cyclodextrin
• aceclofenac
• inclusion complexes
• spray-drying technique

Acknowledgments

The authors are grateful to Emcure Pharmaceutical Ltd, Pune, India, Signet Chemical Corporation Pvt. Ltd, Mumbai, India and M/s Que Pharma Pvt. Ltd., Wadhwan, Gujarat, India, for the gift samples of aceclofenac, β-cyclodextrin, hydroxypropyl-β-cyclodextrin and sodium starch glycollate respectively. This work was supported by a grant from the University of Pune, Maharashtra, India.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.