Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions

Abstract

Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.

Keywords::

• Solid dispersions
• kneading
• PVP K-30
• diclofenac sodium
• dissolution

Acknowledgments

The authors express their gratitude to the National University of Rosario (Argentina) and the National Council Research-CONICET (Argentina) for financial support and to L.M. Salvatierra, for his collaboration in obtaining some experimental data. D.L. gives thanks to National Council Research-CONICET (Argentina) for a fellowship.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.