Abstract
The aim of this study was to develop the formulation of pellets with solid dispersions of piroxicam, and determine the effect of physico-chemical properties of the drug on pharmaceutical availability from solid dispersions and pellets. Two types of piroxicam, varying in crystal size, were used in this study. Presence of the amorphous form in solid dispersions depended on the method of their formulation, and type of piroxicam used. Based on the results of piroxicam release rate from pellets, it was established that the extrusion and spheronization process caused change in the drug release profile in comparison to powder systems, because during the pelletization process, the amorphous form of the piroxicam present in the solid dispersion recrystallizes, and a low-solubility type forms. Better results were obtained using the method, where microcrystalline cellulose cores were coated with solid dispersion.
Acknowledgments
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.