364
Views
5
CrossRef citations to date
0
Altmetric
Research Articles

Development and evaluation of controlled release ibuprofen matrix tablets by direct compression technique

, &
Pages 1-11 | Received 19 Aug 2009, Accepted 03 Nov 2009, Published online: 24 May 2010
 

Abstract

This investigation reports the development and evaluation of controlled release ibuprofen matrix tablets. Matrix tablets weighing 400 mg were fabricated by directly compressing ibuprofen (100 mg) with Eudragit RSPO and Avicel PH 101. The release of ibuprofen was dependant on concentration of Eudragit in the formulation. Varying Eudragit concentration from 10–50% of the formulation (in increments of 5%) revealed that in 4 h, tablets containing 50% Eudragit released about 40% ibuprofen compared to 100% released from tablets containing 10% Eudragit. Following analysis of release mechanism using various models available in literature, release of ibuprofen from matrix tablets was dominated by polymer diffusion-controlled mechanism at least for first 4 h. Thereafter, the release mechanism became more complicated and lost controlled release by diffusion due to change of tablet integrity, such as erosion of polymer matrix. In conclusion, controlled release ibuprofen matrix tablets with desired drug release rate can be fabricated by various formulation variables with direct compression technique.

Acknowledgements

The authors acknowledge St John’s University for providing financial assistance and research facilities to carry out this research.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 523.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.