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Amyloid
The Journal of Protein Folding Disorders
Volume 20, 2013 - Issue 4
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Case Reports

AA amyloidosis in a polyarteritis nodosa patient treated with tocilizumab

Alojzija HočevarDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSloveniaCorrespondence[email protected]
,
Boris LestanDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia
,
Snežna Sodin ŠemrlDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia;Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska KoperSlovenia
,
Katja LakotaDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia
,
Nika KojcFaculty of Medicine, Institute of Pathology, University of Ljubljana LjubljanaSlovenia
,
Nataša PotočnikDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia
&
Matija TomšičDepartment of Rheumatology, University Medical Centre Ljubljana LjubljanaSlovenia;Faculty of Medicine, University of Ljubljana LjubljanaSlovenia
 show all
Pages 275-276 | Received 20 Aug 2013, Accepted 20 Aug 2013, Published online: 09 Oct 2013
 
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Abstract

Amyloid A (AA) (secondary) amyloidosis represents a severe complication of chronic inflammatory diseases. Since pathogenic mechanisms point to the central role of interleukin 6 (IL-6) in the process of amyloid AA generation, IL-6 blockade seems an attractive therapeutic option. We report a case of a patient with polyarteritis nodosa complicated by AA amyloidosis treated with tocilizumab.

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