Assessment of oxidative stress in coronary artery bypass surgery: comparison between the global index OXY-SCORE and individual biomarkers

Abstract

The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, α- and γ-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.

Keywords::

• Malondialdehyde
• glutathione
• oxidative stress global index
• coronary artery bypass graft

Acknowledgement

Declaration of interest: Financial support was received from the Centro Cardiologico Monzino and the Italian Ministry of Health (Ricerca Corrente 2005, Progetto Bio 07). None of the authors had any personal or financial conflict of interest.