Prognostic value of transforming growth factor beta 1 [TGF-β1] and matrix metalloproteinase 9 [MMP-9] in oral squamous cell carcinoma

Abstract

Objectives: The prognostic value of MMP-9 and TGF-β1 in oral squamous cell carcinoma (OSCC) is not clear. This study aimed to assess this subject.

Methods: After immunohistochemistry staining of 48 OSCC biopsies with MMP-9 and TGF-β1 markers, marker expression in the stroma was estimated, and the correlations with OSCC prognosis determinants were analyzed (α = 0.05).

Results: Mode of invasion was associated with metastasis (rho = 0.449, p = 0.008). MMP-9 was positively associated with metastasis and mode of invasion. TGF-β1 was negatively correlated to tumor histologic grade but was positively associated with metastasis.

Conclusions: Unlike TGF-β1, MMP-9 might be useful for prognosis determination.

Keywords::

• Matrix metalloproteinase 9 (MMP-9)
• transforming growth factor beta 1 (TGF-β1)
• oral squamous cell carcinoma (OSCC)
• prognosis

Acknowledgments

The authors thank Dr Hamid Rakhshan and Dr Mojgan Amani for technical contribution to the text and editorial assistance.

Declaration of interest

The authors report no declarations of interest.