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Research Article

Usefulness of serum neopterin levels in acute decompensated heart failure to predict renal dysfunction

, , , , , , & show all
Pages 134-139 | Received 12 Oct 2011, Accepted 20 Nov 2011, Published online: 22 Dec 2011
 

Abstract

Context: Neopterin serum concentration increases in the presence of renal dysfunction.

Objective: We sought to determine the relationship between admission serum neopterin levels and worsening renal function (WRF) in patients with heart failure (HF).

Methods: We prospectively measured serum neopterin levels in patients with HF and the patients were subdivided into two groups: with and without WRF during hospital admission.

Results: Logistic regression analysis showed that high serum neopterin levels at admission were associated with a greater likelihood of developing WRF.

Conclusions: Patients admitted to hospital with HF, elevated serum neopterin levels are associated with an increased risk of developing WRF.

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