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Biomarkers Volume 17, 2012 - Issue 3
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Research Article

Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer

Hyuk-Chan KwonDepartment of Internal Medicine
,
Sung Hyun KimDepartment of Internal Medicine
,
Sung Yong OhDepartment of Internal Medicine
,
Suee LeeDepartment of Internal Medicine
,
Ji Hyun LeeDepartment of Internal Medicine
,
Hong-Jo ChoiDepartment of Surgery
,
Ki-Jae ParkDepartment of Surgery
,
Mee Sook RohDepartment of Pathology, Dong-A University College of Medicine, Busan, Republic of Korea
,
Seung-Geun KimDepartment of Hematology-Oncology, Pusan National University Hospital Medical Research Institute, Busan, Republic of Korea
,
Hyo-Jin KimDepartment of Internal Medicine
&
Jong Hoon LeeDepartment of Internal MedicineCorrespondence[email protected]
 show all
Pages 216-222 | Received 25 Nov 2011, Accepted 09 Jan 2012, Published online: 17 Mar 2012
 
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Abstract

The objective of this study was to clarify whether the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) are significant prognostic markers in patients with resectable colorectal cancer (CRC). A total of 200 patients who underwent curative resection for CRC were enrolled. The NLR and PLR were positively correlated (p < 0.001). Both the NLR and PLR were shown to be good prognostic biomarkers of overall survival (OS) (p = 0.002 and p = 0.001, respectively). The PLR was an independent prognostic factor of OS based on multivariate analysis (hazard ratio, 1.971; 95% confidence interval, 1.102–3.335; p = 0.021).

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