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Biomarkers Volume 17, 2012 - Issue 4
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Research Article

Nasal epithelium integrity, environmental stressors, and allergic sensitization: A biomarker study in adolescents

Antonia SardellaLouvain Centre for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
,
Catherine VoisinLouvain Centre for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
,
Marc NickmilderLouvain Centre for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
,
Xavier DumontLouvain Centre for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
,
Isabella Annesi-Maesano
&
Alfred BernardLouvain Centre for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, BelgiumCorrespondence[email protected]
Pages 309-318 | Received 19 Oct 2011, Accepted 11 Feb 2012, Published online: 17 Mar 2012
 
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Abstract

Changes in the airways epithelium caused by environmental insults might play a role in the development of allergic rhinitis. We measured albumin and Clara cell protein (CC16) in the nasal lavage fluid (NALF) from 474 adolescents (263 girls and 211 boys). The NALF CC16/albumin ratio, integrating the permeability and cellular integrity of the nasal epithelium, decreased mostly with time spent in chlorinated pools. In boys, a lower CC16/albumin ratio in NALF was associated with an increased risk of house dust mite sensitization. The results suggest that the CC16/albumin ratio in NALF can be used to detect nasal epithelium alterations linked to allergic sensitization.

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