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Biomarkers Volume 17, 2012 - Issue 6
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Research Article

The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea

Alan H. B. WuUniversity of California, San Francisco, San Francisco CA, USACorrespondence[email protected]
,
Jeffrey TabasUniversity of California, San Francisco, San Francisco CA, USA
,
Johnathan SteinUniversity of California, San Francisco, San Francisco CA, USA
,
Mihael PotockiUniversity Hospital Basel, Basel Switzerland
,
Christian MuellerUniversity Hospital Basel, Basel Switzerland
,
James McCordHenry Ford Health System, Detroit, MI, USA
,
Mark RichardsUniversity of Otago, Christchurch, New Zealand
,
Oliver HartmannThermo Fisher Aktiengesellschaft Biotechnology Center Henningsdorf, Berlin, Germany
,
Richard NowakHenry Ford Health System, Detroit, MI, USA
,
W. Frank PeacockThe Cleveland Clinic, Cleveland, OH, USA
,
Piotr PonikowskiMedical University, Faculty of Public Health, Wroclaw Poland
,
Martin MoeckelCharitie, Campus Virchow-Klinikum, Berlin, Germany
,
Christopher HoganVirginia Commonwealth University, Richmond, VA, USA
,
Gerasimos S. FilippatosAthens University Hospital, Attikon, Athens, Greece
,
Salvatore Di SommaSant’Andrea Hospital, University La Sapienza, Rome, Italy
,
Inder AnandVA Medical Center, Minneapolis, MN, USA
,
Leong NgUniversity of Leicester, Leicester, United Kingdom
,
Sean-Xavier NeathUniversity of California, San Diego CA, USA
,
Robert ChristensonUniversity of Maryland, Baltimore, MD, USA
,
Nils G. MorgenthalerThermo Fisher Aktiengesellschaft Biotechnology Center Henningsdorf, Berlin, Germany
,
Stefan D. AnkerCentre for Clinical and Basic Research IRCCS San Raffaele, Rome, Italy
&
Alan S. MaiselUniversity of California, San Diego CA, USA
 show all
Pages 490-497 | Received 17 Feb 2012, Accepted 17 Apr 2012, Published online: 23 May 2012
 
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Abstract

Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.

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