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Biomarkers Volume 17, 2012 - Issue 7
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Research Article

Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis

Wenru Tang
,
Xuhong ZhouFlower Research Institute of Yunnan Academy of Agricultural Sciences, Kunming, China
,
Shengjie NieKunming Medical University, Kunming, China
,
Zhi YangKunming Medical University, Kunming, China
,
Hui ZhuLaboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, Kunming, China
,
Xiaoming WuLaboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, Kunming, China
,
Ruoping ZhaoState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
&
Ying LuoCorrespondence[email protected]
 show all
Pages 597-603 | Received 13 May 2012, Accepted 17 Jun 2012, Published online: 10 Jul 2012
 
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Abstract

Background: p53 tumor suppressor gene Arg72Pro polymorphism has been associated with gastric cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and gastric cancer.

Methods: An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assess by pooled odds ratio (ORs) with 95% confidence interval (CIs).

Results: The meta-analysis suggested that the p53 Arg72Pro was associated with the gastric cancer risk (Additive model: OR = 1.149, 95% CI = 1.045–1.263, p = 0.004; Dominant model: OR = 1.18, 95% CI = 1.049–1.328, p = 0.006; Recessive model: OR = 1.202, 95% CI = 1.013–1.427, p = 0.035) in Asian subgroup.

Conclusion: This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.

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