Advanced search
Publication Cover
Biomarkers Volume 18, 2013 - Issue 2
Submit an article Journal homepage
344
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer

Le FuDepartment of Radiology, Huashan Hospital of Fudan University ShanghaiChina
,
Wei GuoDepartment of Nephrology, Children’s Hospital of Fudan University ShanghaiChina
,
Bingshan LiuDepartment of Hematology and Oncology, the 155 Centre Hospital of PLA KaifengChina
,
Linlin SunDepartment of Radiology, Huashan Hospital of Fudan University ShanghaiChina
,
Zhenghong BiDepartment of Radiology, Huadong Hospital of Fudan University ShanghaiChina
,
Li ZhuDepartment of Radiology, Shanghai Chest Hospital of Shanghai Jiaotong University ShanghaiChina
,
Xinyan WangDepartment of Radiology, Huashan Hospital of Fudan University ShanghaiChina
,
Bin LiuDepartment of Radiology, Huashan Hospital of Fudan University ShanghaiChina
,
Qian XieDepartment of Radiology, Huashan Hospital of Fudan University ShanghaiChina
&
Ke LiDepartment of Radiology, Huashan Hospital of Fudan University ShanghaiChinaCorrespondence[email protected] [email protected]
 show all
Pages 126-135 | Received 27 Sep 2012, Accepted 16 Nov 2012, Published online: 14 Feb 2013
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Objective: The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.

Materials and methods: We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.

Results: Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.

Acknowledgements

We thank Yan Yu and Hua Chao for their help in immunohistochemistry.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 527.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.