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Biomarkers Volume 18, 2013 - Issue 2
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Research Article

Serum fetuin-A levels are associated with the presence and severity of coronary artery disease in patients with type 2 diabetes

Zi-Wen ZhaoDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. China
,
Chao-Gui LinDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. China
,
Ling-Zhen WuDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. China
,
Yu-Kun LuoDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. China
,
Lin FanDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. China
,
Xian-feng DongDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. China
&
Hong ZhengDepartment of Cardiology, Union Hospital, Fujian Institute of Coronary Artery Disease, Fujian Medical University FuzhouP. R. ChinaCorrespondence[email protected]
 show all
Pages 160-164 | Received 14 Oct 2012, Accepted 26 Dec 2012, Published online: 14 Feb 2013
 
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Abstract

Objective: To clarify the correlation between serum fetuin-A levels and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes (T2DM).

Methods: A total of 241 consecutive patients with T2DM and 69 controls were recruited. Serum fetuin-A levels were analyzed by enzyme-linked immunosorbent assay. The presence and severity of CAD were evaluated by coronary angiography (CAG).

Results: Serum fetuin-A levels are independently correlated with the presence and severity of CAD in T2DM patients.

Conclusions: Fetuin-A might serve as a potential biomarker for reflecting the development and progression of CAD in T2DM patients.

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