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Biomarkers Volume 18, 2013 - Issue 4
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Research Article

Prognostic value of HOXB7 mRNA expression in human oesophageal squamous cell cancer

Xuan XieState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China
,
Shui-shen ZhangState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China
,
Jing WenState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China
,
Hong YangState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China
,
Kong-jia LuoState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China
,
Fu YangState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China
,
Yi HuState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China
&
Jian-hua FuState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of China;Guangdong Esophageal Cancer Research Institute GuangzhouPeople’s Republic of China;Department of Thoracic Surgery, Sun Yat-sen University Cancer Center GuangzhouPeople’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 297-303 | Received 26 Oct 2012, Accepted 01 Feb 2013, Published online: 29 Apr 2013
 
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Abstract

Objective: This study was to determine the role of HOXB7 in predicting outcomes of patients with oesophageal squamous cell cancer (OSCC).

Methods: Samples were collected from 179 OSCC patients. HOXB7 mRNA expression was measured by quantitative real-time polymerase chain reaction.

Results: HOXB7 mRNA expression was up-regulated in 85.1% of OSCC tumorous tissues, and correlated with age, pathological T and N category, as well as cancer-specific survival (CSS). However, subgroup analysis revealed its discernibility on CSS was only pronounced in early stage.

Conclusions: HOXB7 mRNA expression might serve as a novel prognostic biomarker for resected OSCC patients in early stage.

Acknowledgements

The authors gratefully acknowledge the contribution of all the patients who participated in the study. We also thank Dr Zhiyong Guo from the First Affiliated Hospital of Sun Yat-sen University for his help in English editing of this manuscript.

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