Urinary α- and π-glutathione s-transferases for early detection of acute kidney injury following cardiopulmonary bypass

Abstract

Context: Urinary α-GST and π-GST are renal tubular leakage markers.

Objective: To evaluate the performance characteristics of these markers for the early detection of acute kidney injury (AKI).

Materials and methods: Multicenter prospective cohort study of 252 adults undergoing cardiopulmonary bypass (CPB).

Results: AKI developed in 72 patients. The 2 h post-CPB π-GST level modestly predicted the development of AKI, including higher stages of severity, whereas α-GST did not.

Discussion: Small number of events and absence of subsequent post-operative biomarker measurements.

Conclusions: Among adults undergoing CPB, urinary π-GST outperformed α-GST for predicting AKI, but neither marker displayed good discrimination.

• α-GST
• π-GST
• acute kidney injury
• cardiopulmonary bypass
• urine biomarker

Acknowledgements

This study was presented in part at the American Society of Nephrology 2012 Kidney Week, San Diego, California, 1 November 2012.