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Biomarkers Volume 18, 2013 - Issue 4
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Research Articles

Trefoil Factor 1 as a marker of mucosal damage of the gastrointestinal tract in children with sepsis

Jiří ŽurekDepartment of Anesthesia and Intensive Care, University Children's HospitalCzech RepublicCorrespondence[email protected]
&
Michal FedoraDepartment of Anesthesia and Intensive Care, University Children's HospitalCzech Republic
Pages 338-342 | Received 30 Jan 2013, Accepted 04 Mar 2013, Published online: 29 Apr 2013
 
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Abstract

Intestinal ischemia and reperfusion is a common pathway for many diseases in children. The objective of our study was an analysis of Trefoil factor 1 levels dynamics in patients with SIRS or septic condition during a 5-day period. Analysis of TFF1 levels dynamics revealed that TFF1 levels kept steady state during the 5-day period. TFF1 levels were similar in patients with SIRS, sepsis and severe sepsis. Significantly higher levels of TFF1 were in patients with septic shock and MODS.

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