Advanced search
Publication Cover
Biomarkers Volume 18, 2013 - Issue 7
Submit an article Journal homepage
238
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Hyunsoo ChungTissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MDUSA
,
Hanbyoul ChoDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine SeoulKorea
,
Candice PerryTissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MDUSA
,
Jaekyung SongDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine SeoulKorea
,
Kris YlayaTissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MDUSA
,
Heejeong LeeDepartment of Pathology, Bucheon St. Mary’s Hospital, The Catholic University of Korea SeoulKoreaCorrespondence[email protected]
[email protected]
&
Jae-Hoon KimDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine SeoulKoreaCorrespondence[email protected]
 show all
Pages 573-579 | Received 26 May 2013, Accepted 18 Jul 2013, Published online: 19 Aug 2013
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer.

Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined.

Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).

Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 527.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.