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Research Article

Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver

, , , , , , , , , & show all
Pages 706-715 | Received 03 Jun 2013, Accepted 17 Sep 2013, Published online: 21 Oct 2013
 

Abstract

Objective: Investigation on whether the characteristic molecular signatures can discriminate individual volatile organic compounds (VOCs) and provide predictive markers for the detection of VOC exposure.

Methods: Transcriptomic analysis of liver tissues was performed 48 h after the single oral administration of three VOCs doses at LD25 or LD5 values, to Sprague-Dawley.

Results: Combination analysis of different multi-classifications suggested that 145 genes predicted VOC exposure. Additionally, Gene Set Enrichment Analysis of genes deregulated by VOCs revealed that T cell prolymphatic leukemia signaling was inactivated in all VOCs.

Conclusions: These molecular markers could be widely implemented to assess and predict environmental exposure to VOCs.

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