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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

Evaluation of elevated urinary enolase I levels in patients with endometriosis

Bo Hyon YunDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea;Institute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea
,
You Sun LeeInstitute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea;Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea
,
Seung Joo ChonDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea;Institute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea
,
Yeon Soo JungDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea;Institute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea
,
Su Youn YimDepartment of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea
,
Hye Yeon KimInstitute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea;Department of Obstetrics and Gynecology, YongIn Severance Hospital, Yonsei University College of Medicine Yongin, Kyunggi-doRepublic of Korea
,
Joo Hyun ParkInstitute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea;Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea
,
Seok Kyo SeoDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea;Institute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea
,
SiHyun ChoInstitute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea;Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine SeoulRepublic of KoreaCorrespondence[email protected]
,
Young Sik ChoiDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea;Institute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea
&
Byung Seok LeeInstitute of Women’s Life Medical Science, Yonsei University College of Medicine SeoulKorea;Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine SeoulRepublic of Korea
 show all
Pages 16-21 | Received 27 Aug 2013, Accepted 05 Nov 2013, Published online: 28 Nov 2013
 
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Abstract

Objective: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis.

Methods: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients’ urine.

Results: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713–0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively.

Conclusion: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.

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