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Research Article

Evaluation of nestin in lung adenocarcinoma: relation to VEGF and Bcl-2

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Pages 29-33 | Received 29 Sep 2013, Accepted 05 Nov 2013, Published online: 28 Nov 2013
 

Abstract

Context: Nestin is a marker of multipotent precursor cells that is up regulated in cancer.

Objective: To explore its diagnostic role and its relationship to vascular endothelial growth factor (VEGF) and Bcl-2 in lung adenocarcinoma.

Materials and methods: Evaluation of nestin expression in lung biopsies by real-time PCR and serum VEGF and Bcl-2 by ELISA in 27 adenocarcinoma patients and 15 control subjects.

Results: Nestin was significantly higher in lung adenocarcinoma patients especially with advanced grade and stage and it was significantly correlated to VEGF and Bcl-2.

Conclusion: Nestin can be considered as a potential diagnostic marker in lung adenocarcinoma.

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