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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer

Meixiang SangDepartment of Obstetrics and Gynecology, Bethune International Peace Hospital Shijiazhuang, HebeiPeople’s Republic of China;Tumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China
,
Xiaohua WuDepartment of Obstetrics and Gynecology, Bethune International Peace Hospital Shijiazhuang, HebeiPeople’s Republic of ChinaCorrespondence[email protected]
,
Xiaojie FanTumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China
,
Meijie SangTumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China;Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Science, University of Toyama Sugitani, ToyamaJapan
,
Xinliang ZhouTumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China
&
Nan ZhouDepartment of Obstetrics and Gynecology, Bethune International Peace Hospital Shijiazhuang, HebeiPeople’s Republic of China
Pages 34-42 | Received 28 Jul 2013, Accepted 10 Nov 2013, Published online: 10 Dec 2013
 
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Abstract

Ovarian cancer is a leading cause of death among gynecologic malignancies. In this study, we reported the expression of melanoma-associated antigens A (MAGE-A) genes in peripheral blood from 80 patients with ovarian cancer and 30 healthy donors. MAGE-As expression was associated with the factors indicating poor prognosis. The expressions of MAGE-As and each individual MAGE-A genes were also associated with low overall survival of patients with ovarian cancer. Our results suggested MAGE-A genes may have the potential to be surveillance markers for the detection of circulating tumor cells and represent a poor prognosis for patients with ovarian cancer.

Acknowledgements

The authors would like to greatly appreciate Dr. Qianglin Duan, a skilled English proofreader from Tongji University for paper revision.

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