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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

The association of UGT1A1*6 and UGT1A1*28 with irinotecan-induced neutropenia in Asians: a meta-analysis

Yi-Jing ChenDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChina
,
Fei HuDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChina
,
Chun-Yan LiDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChina
,
Jue-Min FangDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChina
,
Li ChuDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChina
,
Xi ZhangDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChina
&
Qing XuDepartment of Medical Oncology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine ShanghaiChinaCorrespondence[email protected]
 show all
Pages 56-62 | Received 18 Sep 2013, Accepted 17 Nov 2013, Published online: 06 Dec 2013
 
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Abstract

Background: The UGT1A1*28 polymorphism is known as a biomarker of irinotecan-induced neutropenia in Caucasians. However, in Asians, the UGT1A1*28 mutation is much less frequent.

Methods: A meta-analysis was performed to assess the association of the UGT1A1*6 and UGT1A1*28 with neutropenia in Asians.

Results: In a combination test of the two variations, patients with severe neutropenia displayed a 155% higher mutational load than those that were not neutropenic (ORG = 2.55; 95% CI: 1.82–3.58).

Conclusions: In Asians, a combination test of UGT1A1*6 and UGT1A1*28 might be a potential biomarker of irinotecan-induced neutropenia, an observation that will need additional trials for confirmation.

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