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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

Expression and prognostic significance of CIP2A in cutaneous malignant melanoma

Feng ShiDepartment of Dermatology and Venereology, Nantong University Nantong, JiangsuChina
,
Yayun DingDepartment of Dermatology and Venereology, Nantong University Nantong, JiangsuChina
,
Shaoqing JuSurgical Comprehensive Laboratory, Affiliated Hospital of Nantong University Nantong, JiangsuChinaCorrespondence[email protected]
,
Xinhua WuSurgical Comprehensive Laboratory, Affiliated Hospital of Nantong University Nantong, JiangsuChina
&
Shuanglin CaoDepartment of Dermatology and Venereology, Affiliated Hospital of Nantong University Nantong, JiangsuChina
Pages 70-76 | Received 03 Nov 2013, Accepted 01 Dec 2013, Published online: 27 Dec 2013
 
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Abstract

Objective: We investigated the expression and clinical significance of Cancerous inhibitor of protein phosphatase 2A (CIP2A) in Cutaneous malignant melanoma (CMM).

Methods: CIP2A expression was analyzed by immunohistochemistry and western blot. We tested the invasion and migration capability of A375 cells with Matrigel invasion assay, Scratch migration assay and Matrigel migration assay after down-regulating CIP2A expression using siRNA.

Results: CIP2A immunostaining level was correlated with Breslow thickness, Clark’s Level and lymphovascular invasion. High-CIP2A expression implied poor survival for patients. Downregulation of CIP2A attenuated metastasis of CMM cells.

Conclusions: CIP2A may serve as a novel marker to predict the prognosis for CMM patients.

Acknowledgements

The authors thank all the people and patients who participated in this study.

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