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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

The association between c.1333C > T genetic polymorphism of MTHFR gene and the risk of congenital heart diseases

Qiguang WangDepartment of Cardiology, Xijing Hospital, Fourth Military Medical University Xi'an, Shanxi ProvincePeople’s Republic of China
,
Xianyang ZhuDepartment of Congenital Heart Disease, General Hospital of Shenyang Military Area Command Shenyang, Liaoning ProvincePeople’s Republic of ChinaCorrespondence[email protected]
,
Bei LvDepartment of Congenital Heart Disease, General Hospital of Shenyang Military Area Command Shenyang, Liaoning ProvincePeople’s Republic of China
,
Xia LiDepartment of Congenital Heart Disease, General Hospital of Shenyang Military Area Command Shenyang, Liaoning ProvincePeople’s Republic of China
&
Jing ZhangDepartment of Congenital Heart Disease, General Hospital of Shenyang Military Area Command Shenyang, Liaoning ProvincePeople’s Republic of China
Pages 77-80 | Received 14 Nov 2013, Accepted 12 Dec 2013, Published online: 06 Jan 2014
 
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Abstract

This study aims to evaluate the influence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on congenital heart diseases (CHD) risk. The frequencies of allelic and genotypic in CHD patients were significantly different from non-CHD controls. Our data suggested that the c.1333C > T genetic polymorphism of MTHFR gene was statistically associated with the increased risk of CHD [TT versus CC: odds ratio (OR) = 2.70, 95% confidence interval (CI) 1.34–5.45, p = 0.005; T versus C: OR = 1.38, 95% CI 1.03–1.86, p = 0.032]. Our findings indicate that the c.1333C > T genetic polymorphism influences CHD risk in the studied population.

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