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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer

Chen-Sheng LiDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChina
,
Shu-Xiang ZhangDepartment of Critical-Care Medicine, Qianfoshan Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChina
,
Hong-Jun LiuDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChina
,
Yu-Long ShiDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChina
,
Le-Ping LiDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChina
,
Xiao-Bo GuoDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChina
&
Zhen-Hai ZhangDepartment of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong ProvinceChinaCorrespondence[email protected]
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Pages 81-85 | Received 13 Nov 2013, Accepted 14 Dec 2013, Published online: 13 Jan 2014
 
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Abstract

The purpose of the study was to explore the significance of FGFR4 protein expression in colorectal cancer. Immunohistochemistry showed 46.8% (148/316) tumors positive for FGFR4 and 7.3% (23/316) for adjacent normal specimens. FGFR4 positivity was correlated with shortened disease free survival (DFS) and overall survival (OS). Multivariate analysis revealed that FGFR4 was an independent prognostic factor. FGFR4 silencing markedly reduced the migration and invasion capacity of colorectal cancer cell lines. These results suggest FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.

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