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Biomarkers Volume 20, 2015 - Issue 2
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Research Article

Persistent organic pollutants and promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene

Soo Yeun ParkColorectal Cancer Center, Kyunpook National University Medical Center, School of Medicine, Kyunpook National University, Daegu, Korea,
,
Ki-Su KimDepartment of Preventive Medicine and
,
Yu-Mi LeeDepartment of Preventive Medicine and
,
Mi-Jin KimDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea,
,
David R. Jacobs JrDivision of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA,
,
Miquel PortaHospital del Mar Institute of Medical Research (IMIM), School of Medicine, Universitat Autonoma de Barcelona, CIBERESP, Spain, and
,
Dong-Sun KimDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea, ;BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, KoreaCorrespondence[email protected]
&
Duk-Hee LeeDepartment of Preventive Medicine and ;BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, KoreaCorrespondence[email protected]
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Pages 136-142 | Received 21 Oct 2014, Accepted 23 Dec 2014, Published online: 14 Jan 2015
 
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Abstract

Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend = 0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic < 0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.

Declaration of interest

This work was partly supported by grants from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI13C0715) and the National Research Foundation of Korea (No. 2013R1A2A2A01068254).

Supplementary material available online

Supplementary Tables 1 and 2

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