Reproducibility of cardiac biomarkers response to prolonged treadmill exercise

Abstract

We examined the reproducibility of alterations in cardiac biomarkers after two identical bouts of prolonged exercise in young athletes. Serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were assessed before and after exercise. Significant rises in median hs-cTnT and NT-proBNP occurred in both trials. While the absolute changes in hs-cTnT were smaller after trial 2, the pattern of change was similar and the delta scores were significantly related. However, the change in NT-proBNP was not correlated between trials. The hs-cTnT release demonstrates some consistency after exercise although the blunted hc-cTnT response requires further study.

• Cardiac function
• endurance run
• highly sensitive cardiac troponin T
• N-terminal pro-B-type natriuretic peptide

Acknowledgements

The authors would like to express their thanks to Ping Hong, Baoxin Feng, Weiying Zhang, Peifang Zong and Wenyuan Shang for their excellent technical assistance. The cooperation of the subjects is greatly appreciated.