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Biomarkers Volume 19, 2014 - Issue 6
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Research Article

Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients

Irene CiancarelliDepartment of Medicine, Health, and Environmental Sciences, University of L'Aquila L'AquilaItaly;Nova Salus Rehabilitation and Nursing Home Trasacco (L'Aquila)Italy
,
Daniela De AmicisDepartment of Medicine, Health, and Environmental Sciences, University of L'Aquila L'AquilaItaly
,
Caterina Di MassimoDepartment of Medicine, Health, and Environmental Sciences, University of L'Aquila L'AquilaItaly
,
Carla Di ScannoDepartment of Medicine, Health, and Environmental Sciences, University of L'Aquila L'AquilaItaly
,
Caterina PistariniDepartment of Neurorehabilitation, Coma, and Spinal Units, Salvatore Maugeri Foundation PaviaItaly
,
Nicolantonio D'OrazioDepartment of Clinical and Experimental Sciences, University of Chieti ChietiItaly
&
Maria Giuliana Tozzi CiancarelliDepartment of Medicine, Health, and Environmental Sciences, University of L'Aquila L'AquilaItalyCorrespondence[email protected]
 show all
Pages 452-456 | Received 14 Apr 2014, Accepted 14 Jun 2014, Published online: 01 Jul 2014
 
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Abstract

Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).

Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2′-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.

Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.

Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.

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