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Biomarkers Volume 19, 2014 - Issue 6
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Research Article

Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice

David GoodwinDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA
,
Barry RosenzweigDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA
,
Jun ZhangDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA
,
Lin XuDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA
,
Sharron StewartDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA
,
Karol ThompsonDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA
&
Rodney RouseDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSACorrespondence[email protected]
 show all
Pages 517-529 | Received 01 Jul 2014, Accepted 09 Jul 2014, Published online: 25 Jul 2014
 
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Abstract

Mild injury of the exocrine pancreas is often asymptomatic and can be under- or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exocrine pancreas injury in rodent models of acute pancreatitis induced by caerulein, l-arginine, and pancreatic duct ligation. Both microRNAs showed time- and dose- relevant responses to pancreatic injury and wider dynamic ranges of response than serum amylase or lipase. Pancreas-selective microRNAs were found to be relatively sensitive serum biomarkers of pancreatic injury in rodents with potentially greater specificity than the current standard assays.

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