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Biomarkers Volume 19, 2014 - Issue 7
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Research Articles

Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma

WenHao RenDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Cui QiangDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Ling GaoDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China;Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi'an Jiaotong University Xi'an, ShaanxiP. R. China
,
Shao-Ming LiDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Lin-Mei ZhangDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Xiao-Long WangDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Jian-Wei DongDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Cheng ChenDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
,
Chang-Yang LiuDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. China
&
Ke-Qian ZhiDepartment of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an ShaanxiP. R. ChinaCorrespondence[email protected]
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Pages 590-596 | Received 13 Jun 2014, Accepted 12 Aug 2014, Published online: 01 Sep 2014
 
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Abstract

The purpose of this study was to investigate the potential of the blood levels of MIR-21 and PTEN as novel biomarkers for oral squamous cell carcinoma (OSCC). We initially detected MIR-21 and PTEN using real-time RT-PCR from 90 blood samples and then compared their results with expression in cancer tissues from 10 OSCC patients. Finally, we examined the relationship between these markers and clinical parameters. Blood MIR-21 and PTEN had significant diagnostic value for OSCC and, to an extent, correlated with the expression level of tumour MIR-21 and PTEN. In addition, they were associated with differentiation and nodal status. Thus circulating MIR-21 and PTEN might represent new complementary tumour markers for OSCC.

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