Profile of the porcine acute-phase proteins response following experimental co-infection with H3N2 swine influenza virus and Pasteurella multocida

Abstract

Context: Acute phase proteins (APPs) are proposed as potential markers of the health status in pigs.

Objective: Circulating APPs in pigs co-infected with swine influenza virus and Pasteurella multocida.

Methods: Serum APPs were measured in co-infected and control pigs with the use of commercial ELISA tests.

Results: All investigated APPs revealed significant changes in co-infected pigs during the study period. The concentration of C-reactive protein, haptoglobin and serum amyloid A (SAA) increased significantly at 2 dpi, before respiratory signs and fever were observed. Concentration of Pig-MAP increased significantly at 3 dpi. C-reactive protein and SAA reaction were rapid but short-lived. The concentration of Hp and Pig-MAP in serum also increased at very early stage of co-infection but remained elevated for a longer period of time.

Conclusions: Maximal concentration of serum amyloid A correlated with the disease severity in pigs.

• Biomarkers
• disease severity
• pig
• respiratory infection

Declaration of interest

The authors report no declarations of interest. This work was supported by Polish Ministry of Science and Higher Education under grant no. N308 235938.