Abstract
Little is known about polymorphic distribution of pharmacogenes among ethnicities, including the Deng people. In this study, we recruited 100 unrelated, healthy Deng people and genotyped them with respect to 76 different single-nucleotide polymorphisms by the PharmGKB database. Our results first indicated that the polymorphic distribution of pharmacogenes of the Deng people is most similar to CHD, suggesting that Deng people have a closest genetic relationship with CHD. Our data will enrich the database of pharmacogenomics and provide a theoretical basis for safer drug administration and individualized treatment plans, promoting the development of personalized medicine.
Acknowledgements
The authors would like to thank BioScience Writers for the assistance in the preparation of this article.
Declaration of interest
The authors report no declarations of interest. This work is supported by Natural Science Foundation of Xizang (Tibet) Autonomous Region (20152R-13-11), Major Training Program of Tibet University for Nationalities (No. 13myZP06), Natural Science Foundation of Xizang (Tibet) Autonomous Region (2010) and Major science and technology research projects of Chinese Ministry of Education (No. 211176).
Supplementary material available online
Supplementary Tables S1-S3.