Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease

Abstract

Context: Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease.

Objective: To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients.

Methods: Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years.

Results: Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period.

Conclusion: Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients.

• Adipokine
• adipose tissue
• cytokine
• morbidity
• renal disease

Declaration of interest

This work was supported by the Special Research Accounts of Athens University (Associate Professor Maria Dalamaga, Code 70/4/9139). The authors report no declarations of interest.