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Original Article

A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson’s disease

, , , , , , , , , , , & show all
Pages 129-137 | Received 16 Apr 2015, Accepted 01 Nov 2015, Published online: 03 Dec 2015
 

Abstract

Context: Sensitive, non-invasive biomarkers that facilitate Parkinson’s disease (PD) detection and stage assignment are currently unavailable.

Objective: The objective of this study is to investigate the potential of circulating microRNAs (miRNAs) as novel biomarkers for PD.

Materials and methods: Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients.

Results: Serum miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in PD patients compared with controls. Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls.

Discussion and conclusion: The four serum miRNAs may represent novel biomarkers for the early detection of PD.

Supplementary material available online Supplemental data Tables 1–9

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