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Biomarkers Volume 21, 2016 - Issue 2
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Research Article

Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint

Qiang JiaoDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
,
Lei WeiDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and ;Department of Orthopedics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA
,
Chongwei ChenDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
,
Pengcui LiDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
,
Xiaohu WangDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
,
Yongping LiDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
,
Li GuoDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
,
Congming ZhangDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and
&
Xiaochun WeiDepartment of Orthopedics, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People’s Republic of China and Correspondence[email protected]
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Pages 146-151 | Received 05 Jun 2015, Accepted 01 Nov 2015, Published online: 03 Dec 2015
 
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Abstract

The purpose of this study was to evaluate the relationship between five previously established serum osteoarthritis biomarkers and the severity of cartilage lesions in the knee. Cartilage damage (classified according to the Outerbridge scoring system) and serum concentrations of cartilage oligomeric matrix protein (COMP), collagen type II C-telopeptide (CTX-II), matrix metalloproteinase-3 (MMP-3), collagen type III N-propeptide, (PIIINP), and hyaluronic acid (HA) were determined in 79 patients who underwent knee arthroscopy or total knee replacement. HA and COMP concentrations were significantly higher in the Outerbridge score 1 and 2 groups, respectively. These results suggest that serum COMP and HA concentrations can be used to predict early cartilage lesions in the knee.

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