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Research Article

Acute nephrotoxicity of aristolochic acid in vitro: metabolomics study for intracellular metabolic time-course changes

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Pages 233-242 | Received 18 May 2015, Accepted 17 Dec 2015, Published online: 05 Feb 2016
 

Abstract

Time-course metabolic changes of aristolochic acid nephrotoxicity (AAN) was investigated using acute AAN HK-2 model. And the AAN-related biomarkers were selected. In the results, 11 potential identified biomarkers were selected and validated using multivariate method combined with time-course analysis. Several metabolic pathways, including vitamin metabolism, lipids acalytion, trytophan metabolism and protein degradation were found to be associated with AAN pathology. This research will provide a valuable reference for the discovery of more potential biomarkers of AAN progression in clinic.

Author contributions

Xiaoyan liu is responsible for main experiment working and article writing. Yanqiu Liu and Mengchun Cheng are responsible for technical support. Hongbin Xiao is responsible for the experiment design.

Declaration of interest

The authors declare no conflict of interests.

This work was supported by grants from National Technology Major Project (2014ZX09304307-001-006).

Supplementary material available online Supplementary Figures S1(a, b), S3 and S4

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