Advanced search
Publication Cover
Biomarkers Volume 21, 2016 - Issue 4
Submit an article Journal homepage
212
Views
2
CrossRef citations to date
0
Altmetric
Research Article

The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients

Rasa UgenskienėOncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania, Correspondence[email protected]
,
Dana MyrzaliyevaOncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania, and
,
Roberta JankauskaitėOncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania,
,
Jurgita GedminaitėOncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania, and
,
Rasa JančiauskienėOncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania, and
,
Eglė ŠepetauskienėCenter of Informatics Technologies, Lithuanian University of Health Sciences, Kaunas, Lithuania
&
Elona JuozaitytėOncology Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania, and
show all
Pages 363-370 | Received 23 Apr 2015, Accepted 10 Jan 2016, Published online: 22 Feb 2016
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

The germline polymorphisms in signal-inducing proliferation-associated protein 1 (SIPA1) and ribosomal RNR processing 1B (RRP1B) might be involved in breast cancer metastasis. The aim of this study was to analyze how SIPA1 and RRP1B polymorphisms contribute to breast cancer phenotype, lymph node status and survival. A group of 100 young, I–II stage breast cancer patients were analyzed for SIPA1 and RRP1B polymorphisms with PCR-RFLP assay. SIPA1 c.2760G > A, c.545C > T and RRP1B c.436T > C polymorphisms were associated with lymph node status, survival and tumor grade, respectively. Our results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis.

Acknowledgements

We are grateful to the patients for their participation in this research.

Declaration of interest

The authors report no declaration of interest.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 527.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.