Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma

Abstract

We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC.

Keywords:

• Biomarker
• diagnosis
• esophageal cancer
• miR-1297
• qRT-PCR,

Disclosure statement

The authors report no declarations of interest.

Funding information

This study was supported by National Natural Science Foundation of China (no. 81572958) and Science and Technology Development Planning Project of Shandong Province (2014GSF118058).