Abstract
This study assessed oxidatively damaged DNA and antioxidant enzyme activity in workers occupational exposure to metal oxides nanomaterials. Exposure to TiO2, SiO2, and ITO resulted in significant lower antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and higher oxidative biomarkers 8-hydroxydeoxyguanosine (8-oxodG) than comparison workers. Statistically significant correlations were noted between plasma and urine 8-oxodG, between white blood cells (WBC) and urine 8-oxodG, and between WBC and plasma 8-oxodG. In addition, there were significant negative correlations between WBC 8-oxodG and SOD and between urinary 8-oxodG and GPx levels. The results showed that urinary 8-oxodG may be considered to be better biomarker.
Disclosure statement
The authors declare that there is no conflict of interest.
Funding information
This study was supported by Ministry of Science and Technology (Grant No. NSC102-2113-M-030-005-MY2, NSC102-2314-B-400-002, MOST 103-2314-B-400-005-MY2), National Health Research Institutes of Taiwan (grants 98A1-EOSP03-014, 99A1-EOSP03-014, 00A1-EOSP03-014, and 01A1-EOSP03-014), and the Institute of Occupational Safety and Health, Taiwan (grants IOSH98-M323, IOSH99-M323, IOSH100-M323, and IOSH101-M323). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of Taiwan National Health Research Institutes.