Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries

Abstract

Purpose: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas.

Methods: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset.

Results: Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis.

Conclusions: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas.

Keywords:

• Multiple organ failure
• severe sepsis
• suPAR
• trauma

Disclosure statement

None of the authors has any conflict of interest related to this submission.

Funding information

The study was funded in part by (a) the Hellenic Institute for the Study of Sepsis; and (b) an unrestricted educational grant by ViroGates SA, Copenhagen, Denmark (Grant 70/3/10570) to the University of Athens. The funders had no role in study design, acquisition and analysis of data and in decision to publish.